The blood–brain barrier (BBB) is an important physiological barrier that separates the
central nervous system (CNS) from the peripheral circulation, which contains inflammatory …

The blood–brain barrier (BBB) is a critical regulator of CNS homeostasis. It possesses
physical and biochemical characteristics (ie tight junction protein complexes, transporters) …

A large body of experimental evidence suggests that neuroinflammation is a key
pathological event triggering and perpetuating the neurodegenerative process associated …

The peroxisome proliferator-activated receptor (PPAR) family includes three transcription
factors: PPARα, PPARβ/δ, and PPARγ. PPAR are nuclear receptors activated by oxidised …

Microglia, of myeloid origin, play fundamental roles in the control of immune responses and
the maintenance of central nervous system homeostasis. These cells, just like peripheral …

Intraventricular hemorrhage (IVH) occurs in 20% to 25% of very low birthweight preterm
neonates and may be associated with significant sequelae. Infants who have IVH are at risk …

The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the brain tissue. It facilitates communication while separating the …

Neurodegenerative disorders are marked by extensive neuronal apoptosis and gliosis.
Although several apoptosis-inducing agents have been described, understanding of the …

Background PTEN-induced kinase 1 (PINK1) is linked to recessive Parkinsonism (EOPD).
Pink1 deletion results in impaired dopamine (DA) release and decreased mitochondrial …

The blood-brain barrier (BBB) is a critical regulator of brain homeostasis. Additionally, the
BBB is the most significant obstacle to effective CNS drug delivery. It possesses specific …