Single-cell and spatial molecular profiling assays have shown large gains in sensitivity,
resolution and throughput. Applying these technologies to specimens from human and …

The advent of high-throughput single-cell genomics technologies has fundamentally
transformed biological sciences. Currently, millions of cells from complex biological tissues …

Background Cells and tissues have a remarkable ability to adapt to genetic perturbations via
a variety of molecular mechanisms. Nonsense-induced transcriptional compensation, a form …

We present a comprehensive framework for predicting the effects of perturbations in single
cells, designed to standardize benchmarking in this rapidly evolving field. Our framework …

Over-activation of the epidermal growth factor receptor (EGFR) is a hallmark of glioblastoma.
However, EGFR-targeted therapies have led to minimal clinical response. While delivery of …

Population-scale sequencing efforts have catalogued substantial genetic variation in
humans such that variant discovery dramatically outpaces interpretation. We discuss how …