Bach1: function, regulation, and involvement in disease

X Zhang, J Guo, X Wei, C Niu, M Jia… - … medicine and cellular …, 2018 - Wiley Online Library
The transcription factor BTB and CNC homology 1 (Bach1) is widely expressed in most
mammalian tissues and functions primarily as a transcriptional suppressor by …

The transcription factor BACH1 at the crossroads of cancer biology: from epithelial–mesenchymal transition to ferroptosis

K Igarashi, H Nishizawa, Y Saiki… - Journal of Biological …, 2021 - ASBMB
The progression of cancer involves not only the gradual evolution of cells by mutations in
DNA but also alterations in the gene expression induced by those mutations and input from …

Preparation and characterization of polycaprolactone/chitosan-g-polycaprolactone/hydroxyapatite electrospun nanocomposite scaffolds for bone tissue engineering

IS Sani, M Rezaei, AB Khoshfetrat… - International Journal of …, 2021 - Elsevier
Chitosan (CS) and poly (ε-caprolactone)(PCL) are two most usable polymers in biomedical
applications. In this study, chitosan has been modified and incorporated with poly (ε …

miR‐142‐3p as tumor suppressor miRNA in the regulation of tumorigenicity, invasion and migration of human breast cancer by targeting Bach‐1 expression

B Mansoori, A Mohammadi, M Ghasabi… - Journal of cellular …, 2019 - Wiley Online Library
Background Breast cancer is the most common type of cancer among women, and despite
improved treatments, it remains a major challenge. However, improved mechanistic insight …

[HTML][HTML] Overexpression of BACH1 mediated by IGF2 facilitates hepatocellular carcinoma growth and metastasis via IGF1R and PTK2

M Xie, M Sun, X Ji, D Li, X Chen, B Zhang, W Huang… - Theranostics, 2022 - ncbi.nlm.nih.gov
Background: Accumulating studies manifest that BTB and CNC homology 1 (BACH1)
facilitates multiple malignancies progression and metastasis, and targeting the BACH1 …

miR‐330 suppresses EMT and induces apoptosis by downregulating HMGA2 in human colorectal cancer

B Mansoori, A Mohammadi… - Journal of cellular …, 2020 - Wiley Online Library
MicroRNAs (miRNAs) are important molecular regulatorsof cellular signaling and behavior.
They alter gene expression by targeting messenger RNAs, including those encoding …

BTB and CNC homology 1 (Bach1) promotes human ovarian cancer cell metastasis by HMGA2-mediated epithelial-mesenchymal transition

W Han, Y Zhang, C Niu, J Guo, J Li, X Wei, M Jia, X Zhi… - Cancer Letters, 2019 - Elsevier
Transcriptional factor BTB and CNC homology 1 (Bach1) has been linked to tumor
progression and metastasis, but the mechanisms underlying the effects of Bach1 on tumor …

[HTML][HTML] Pathophysiological role of BACH transcription factors in digestive system diseases

Q Song, X Mao, M Jing, Y Fu, W Yan - Frontiers in Physiology, 2023 - frontiersin.org
BTB and CNC homologous (BACH) proteins, including BACH1 and BACH2, are
transcription factors that are widely expressed in human tissues. BACH proteins form …

[HTML][HTML] Dysregulation of key microRNAs in pancreatic cancer development

B Baradaran, R Shahbazi, M Khordadmehr - Biomedicine & …, 2019 - Elsevier
Pancreatic cancer (PC) is mentioned as one of the fourth major cause of cancer-related
deaths and also is considered as one of the most malignancies worldwide. Sadly, widely …

[HTML][HTML] The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity

L Casares, R Moreno, KX Ali, M Higgins, SD Naidu… - Redox Biology, 2022 - Elsevier
The transcription factor BACH1 is a potential therapeutic target for a variety of chronic
conditions linked to oxidative stress and inflammation, as well as cancer metastasis …