Endothelial cells (ECs) are vascular, nonconventional immune cells that play a major role in
the systemic response after bacterial infection to limit its dissemination. Triggered by …

Coronavirus disease 2019 (COVID-19), currently a worldwide pandemic, is a viral illness
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The …

Non-healing chronic wounds present a major biological, psychological, social, and financial
burden on both individual patients and the broader health system. Pathologically extensive …

The parallel expression of activation products of the coagulation, fibrinolysis, and
complement systems has long been observed in both clinical and experimental settings …

The endothelium is a highly dynamic cell layer that is involved in a multitude of physiological
functions, including the control of vascular tone, the movement of cells and nutrients, the …

Background Sepsis is a common, expensive and frequently fatal condition. There is an
urgent need for developing new therapies to further reduce severe sepsis‐induced mortality …

Proteases are an expanding class of drugs that hold great promise. The US FDA (Food and
Drug Administration) has approved 12 protease therapies, and a number of next generation …

Emerging evidence shows a broad spectrum of biological functions of tissue factor (TF). TF
classical role in initiating the extrinsic blood coagulation and its direct thrombotic action in …

Coagulation and the immune system interact in several physiological and pathological
conditions, including tissue repair, host defense, and homeostatic maintenance. This …

Background Coagulation abnormalities in COVID-19 patients have not been addressed in
depth. Objective To perform a longitudinal evaluation of coagulation profile of patients …