Blood production depends on rare haematopoietic stem cells (HSCs) and haematopoietic
stem and progenitor cells (HSPCs) that ultimately take up residence in the bone marrow …

The bone marrow contains peripheral nerves that promote haematopoietic regeneration
after irradiation or chemotherapy (myeloablation), but little is known about how this is …

Hematopoietic stem cell (HSC) transplantation-based treatments are in different phases of
clinical development, ranging from current therapies to a promise in the repair and …

Lympho-hematopoiesis is regulated by cytokines; however, it remains unclear how
cytokines regulate hematopoietic stem cells (HSCs) to induce production of lymphoid …

Bone marrow aspirate concentrate (BMAC) and adipose-derived stromal vascular fraction
(ADSVF) are the most marketed stem cell therapies to treat a variety of conditions in the …

The hematopoietic system composed of hematopoietic stem and progenitor cells (HSPCs)
and their differentiated lineages serves as an ideal model to uncover generic principles of …

A critical regulatory role of hematopoietic stem cell (HSC) vascular niches in the bone
marrow has been implicated to occur through endothelial niche cell expression of KIT …

Hematopoietic stem cells (HSCs) are the cornerstone of the hematopoietic system. HSCs
sustain the continuous generation of mature blood derivatives while self‐renewing to …

Ageing is a conserved biological process, modulated by intrinsic and extrinsic factors, that
leads to changes in life expectancy. In humans, ageing is characterized by greatly increased …

The central role of the endothelial microenvironment in orchestrating bone marrow (BM)
homeostasis and hematopoietic support has been confirmed at various developmental …