Longitudinal clinical–pathological studies have increasingly recognized the importance of
mixed pathologies (the coexistence of one or more neurodegenerative and cerebrovascular …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease which is mainly
characterized by progressive impairment in cognition, emotion, language and memory in …

Abstract Aims The Valve Academic Research Consortium (VARC), founded in 2010, was
intended to (i) identify appropriate clinical endpoints and (ii) standardize definitions of these …

Since first described in the early 1900s, Alzheimer's disease (AD) has risen exponentially in
prevalence and concern. Research still drives to understand the etiology and pathogenesis …

The global burden of ischaemic strokes is almost 4-fold greater than haemorrhagic strokes.
Current evidence suggests that 25–30% of ischaemic stroke survivors develop immediate or …

Vascular dementia (VaD) is widely recognised as the second most common type of
dementia. Consensus and accurate diagnosis of clinically suspected VaD relies on wide …

Despite the global impact and advances in understanding the pathophysiology of
cerebrovascular diseases, the term “stroke” is not consistently defined in clinical practice, in …

Vascular dementia (VaD) is recognised as a neurocognitive disorder, which is explained by
numerous vascular causes in the general absence of other pathologies. The heterogeneity …

Cerebrospinal fluid (CSF) circulation and turnover provides a sink for the elimination of
solutes from the brain interstitium, serving an important homeostatic role for the function of …

Background White matter hyperintensities (WMH), lacunes and microbleeds are regarded as
typical MRI expressions of cerebral small vessel disease (SVD) and they are highly …