The health benefits of regular exercise are well established. Nonetheless, the molecular
mechanism (s) responsible for exercise-induced health benefits remain a topic of debate …

Abstract Silence information regulator 1 (SIRT1), a member of the sirtuin family, targets
histones and many non-histone proteins and participates in various physiological functions …

Aging is a fundamental biological process accompanied by a general decline in tissue
function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive …

Cardiac aging is evident by a reduction in function which subsequently contributes to heart
failure. The metabolic microenvironment has been identified as a hallmark of malignancy …

Background Although gait disorders strongly contribute to perceived disability in people with
Parkinson's disease, clinical trials have failed to identify which task-oriented gait training …

The key link between renin–angiotensin system (RAS) and COVID-19 is ACE2 (angiotensin-
converting enzyme 2), which acts as a double-edged sword, because ACE2 increases the …

Parkinson's disease is the second most common neurodegenerative disease with a
prevalence rate of 1–2 per 1000 of the population worldwide. Pharmacological management …

Overactivity of the angiotensin-type-1 receptor (AT1)/NADPH-oxidase axis enhances aging
processes, neuroinflammation and neurodegeneration. The role of AT2 receptors in the …

The deacetylase sirtuin 1 (Sirt1), activated by calorie restriction and fasting, exerts several
complementary effects on cellular function that are favourable to healthspan; it is often …

Exercise has been shown to have beneficial effects on brain functions in humans and
animals. Exercise can improve memory and learning in age-related neurodegenerative …