Quantitative phase imaging: recent advances and expanding potential in biomedicine

TL Nguyen, S Pradeep, RL Judson-Torres, J Reed… - ACS …, 2022 - ACS Publications
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …

Live-cell mass profiling: an emerging approach in quantitative biophysics

TA Zangle, MA Teitell - Nature methods, 2014 - nature.com
Cell mass, volume and growth rate are tightly controlled biophysical parameters in cellular
development and homeostasis, and pathological cell growth defines cancer in metazoans …

Quantitative phase imaging for medical diagnosis

H Majeed, S Sridharan, M Mir, L Ma, E Min… - Journal of …, 2017 - Wiley Online Library
Optical microscopy is an indispensable diagnostic tool in modern healthcare. As a prime
example, pathologists rely exclusively on light microscopy to investigate tissue morphology …

Type V collagen in scar tissue regulates the size of scar after heart injury

T Yokota, J McCourt, F Ma, S Ren, S Li, TH Kim… - Cell, 2020 - cell.com
Scar tissue size following myocardial infarction is an independent predictor of
cardiovascular outcomes, yet little is known about factors regulating scar size. We …

The quantitative-phase dynamics of apoptosis and lytic cell death

T Vicar, M Raudenska, J Gumulec, J Balvan - Scientific reports, 2020 - nature.com
Cell viability and cytotoxicity assays are highly important for drug screening and cytotoxicity
tests of antineoplastic or other therapeutic drugs. Even though biochemical-based tests are …

Living cell dry mass measurement using quantitative phase imaging with quadriwave lateral shearing interferometry: an accuracy and sensitivity discussion

S Aknoun, J Savatier, P Bon, F Galland… - … of biomedical optics, 2015 - spiedigitallibrary.org
Single-cell dry mass measurement is used in biology to follow cell cycle, to address effects
of drugs, or to investigate cell metabolism. Quantitative phase imaging technique with …

Label-free hematology analysis using deep-ultraviolet microscopy

A Ojaghi, G Carrazana, C Caruso… - Proceedings of the …, 2020 - National Acad Sciences
Hematological analysis, via a complete blood count (CBC) and microscopy, is critical for
screening, diagnosing, and monitoring blood conditions and diseases but requires complex …

Label-free characterization of white blood cells by measuring 3D refractive index maps

J Yoon, K Kim, HJ Park, C Choi, S Jang… - Biomedical optics …, 2015 - opg.optica.org
The characterization of white blood cells (WBCs) is crucial for blood analyses and disease
diagnoses. However, current standard techniques rely on cell labeling, a process which …

[HTML][HTML] Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair

S Li, T Yokota, P Wang, J Ten Hoeve… - The Journal of …, 2022 - Am Soc Clin Investig
Cardiac wound healing following ischemic injury requires a well-described spatiotemporal
progression of events involving multiple cell types and cell-cell interactions. While cellular …

Topological arrangement of cardiac fibroblasts regulates cellular plasticity

J Yu, MM Seldin, K Fu, S Li, L Lam, P Wang… - Circulation …, 2018 - Am Heart Assoc
Rationale: Cardiac fibroblasts do not form a syncytium but reside in the interstitium between
myocytes. This topological relationship between fibroblasts and myocytes is maintained …