In situ, cells are highly sensitive to geometrical and mechanical constraints from their
microenvironment. These parameters are, however, uncontrolled under classic culture …

Many essential cellular functions in health and disease are closely linked to the ability of
cells to respond to mechanical forces. In the context of cell adhesion to the extracellular …

Remarkable exertions are directed to reveal and understand topographic cues that induce
cell mechanical sensitive responses including lineage determination. Extracellular matrix …

The cellular environment impacts a myriad of cellular functions by providing signals that can
modulate cell phenotype and function. Physical cues such as topography, roughness …

Epithelial cell migration requires coordination of two actin modules at the leading edge: one
in the lamellipodium and one in the lamella. How the two modules connect mechanistically …

From the extracellular matrix to the cytoskeleton, a network of molecular links connects cells
to their environment. Molecules in this network transmit and detect mechanical forces, which …

Integrins in focal adhesions (FAs) mediate adhesion and force transmission to extracellular
matrices essential for cell motility, proliferation and differentiation. Different fibronectin …

Contractile actomyosin networks are responsible for the production of intracellular forces.
There is increasing evidence that bundles of actin filaments form interconnected and …

Recent studies at the nanometer scale have revealed that relatively uniform clusters of
adhesion proteins (50–100 nm) constitute the modular units of cell adhesion sites in both …

The formation of tissues and organs requires cells to adhere to each other and/or to migrate
and polarize in contact with components of the extracellular matrix. The connection between …