Vehicle pollution is an increasing problem in the industrial world. Aromatic nitro compounds
comprise a significant portion of the threat. In this review, the class includes nitro derivatives …

The 5-nitroimidazole drug metronidazole has remained the drug of choice in the treatment of
anaerobic infections, parasitic as well as bacterial, ever since its development in 1959. In …

ABSTRACT Benznidazole, a 2-nitroimidazole, is the front-line treatment used against
American trypanosomiasis, a parasitic infection caused by Trypanosoma cruzi. Despite …

Infectious diseases claim millions of lives every year, but with the advent of drug resistance,
therapeutic options to treat infections are inadequate. There is now an urgent need to …

Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death
worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases …

The use of chemotherapeutic drugs is the main resource against clinical giardiasis due to
the lack of approved vaccines. Resistance of G. duodenalis to the most used drugs to treat …

Cysteine residues can undergo multiple posttranslational modifications with diverse
functional consequences, potentially behaving as tunable sensors. The intermediate …

Entamoeba histolytica is a protozoan parasite and the causative agent of amebiasis. It is
estimated approximately 1% of humans are infected with E. histolytica, resulting in an …

The microaerophilic parasite Giardia lamblia is a causative agent of dysentery affecting
hundreds of millions of people around the globe every year. The symptoms of the disease …

Background The first line treatment for Chagas disease, a neglected tropical disease caused
by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole …