Hypertension is one of the strongest modifiable cardiovascular risk factors, affecting an
increasing number of people worldwide. Apart from poor medication adherence, the low …

Hypertension is a multifactorial disease that affects approximately one billion subjects
worldwide and is a major risk factor associated with cardiovascular events, including …

Several cytochrome P450 (CYP) CYP3A polymorphisms were associated with reduced
enzyme function. We aimed to evaluate the influence of these alleles on the …

Hypertension is a frequent finding in elderly patients. Hypertension in older age can be both
associated with frailty and represent a risk factor for frailty. Hypertension is recognized as a …

Amlodipine is a commonly prescribed calcium channel blocker for the treatment of
hypertension and ischemic heart disease. The drug is slowly cleared in humans primarily via …

Atorvastatin is a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor that
is mainly metabolized by cytochrome P450 (CYP) 3A4. A recent study showed that the lipid …

Abstract Background and Objective: Carbamazepine (CBZ) is metabolized mainly by the
CYP3A family of enzymes, which includes CYP3A4 and CYP3A5. Several studies have …

Purpose To assess the influence of the P450 oxidoreductase* 28 SNP (POR* 28) on
tacrolimus pharmacokinetics in the Chinese population. Methods Seventy-one healthy …

Purpose: To explore the association between CYP3A4 and CYP3A5 gene polymorphisms
and blood pressure response to amlodipine among participants from the African-American …

In this paper, we first give an upper bound for the largest signless Laplacian eigenvalue of a
graph and find all the extremal graphs. Secondly, we consider the second-largest signless …