Materials engineering strategies for cancer vaccine adjuvant development

X Zhang, B Yang, Q Ni, X Chen - Chemical Society Reviews, 2023 - pubs.rsc.org
Cancer vaccines have emerged as a powerful new tool for cancer immunotherapy.
Adjuvants are vaccine ingredients that enhance the strength, velocity, and duration of the …

Three decades of messenger RNA vaccine development

R Verbeke, I Lentacker, SC De Smedt, H Dewitte - Nano Today, 2019 - Elsevier
In the early nineties, pioneering steps were taken in the use of mRNA as a therapeutic tool
for vaccination. In the following decades, an improved understanding of the mRNA …

Cancer as a disease of old age: changing mutational and microenvironmental landscapes

E Laconi, F Marongiu, J DeGregori - British journal of cancer, 2020 - nature.com
Why do we get cancer mostly when we are old? According to current paradigms, the answer
is simple: mutations accumulate in our tissues throughout life, and some of these mutations …

Metalloimmunology: The metal ion-controlled immunity

C Wang, R Zhang, X Wei, M Lv, Z Jiang - Advances in immunology, 2020 - Elsevier
Metals are essential components in all forms of life required for the function of nearly half of
all enzymes and are critically involved in virtually all fundamental biological processes …

Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season

CM Andrade, H Fleckenstein, R Thomson-Luque… - Nature Medicine, 2020 - nature.com
The dry season is a major challenge for Plasmodium falciparum parasites in many malaria
endemic regions, where water availability limits mosquito vectors to only part of the year …

CD8+ T Lymphocyte and NK Cell Network: Circuitry in the Cytotoxic Domain of Immunity

RV Uzhachenko, A Shanker - Frontiers in immunology, 2019 - frontiersin.org
Multiple effector layers in the immune system ensure an optimal temporal and spatial
distribution of immune defense. Cytotoxic innate lymphoid natural killers (NK) and adaptive …

Metal-based nano-vaccines for cancer immunotherapy

J Li, H Ren, Y Zhang - Coordination Chemistry Reviews, 2022 - Elsevier
Cancer vaccination is an effective way to prevent or cure cancers by inducing strong cellular
and humoral immunity with the aid of delivery carriers or adjuvants. Increasing new delivery …

Minding the gut: extending embodied cognition and perception to the gut complex

F Boem, GP Greslehner, JP Konsman… - Frontiers in …, 2024 - frontiersin.org
Scientific and philosophical accounts of cognition and perception have traditionally focused
on the brain and external sense organs. The extended view of embodied cognition suggests …

A part‐dependent account of biological individuality: why holobionts are individuals and ecosystems simultaneously

J Suárez, A Stencel - Biological Reviews, 2020 - Wiley Online Library
Given one conception of biological individuality (evolutionary, physiological, etc.), can a
holobiont–that is the host+ its symbiotic (mutualistic, commensalist and parasitic) …

T cell receptor–triggered nuclear actin network formation drives CD4+ T cell effector functions

N Tsopoulidis, S Kaw, V Laketa, S Kutscheidt… - Science …, 2019 - science.org
T cell antigen receptor (TCR) signaling triggers selective cytokine expression to drive T cell
proliferation and differentiation required for immune defense and surveillance. The nuclear …