In inflammation, extensive cell death may occur, which results in the release of chromatin
components into the extracellular environment. Individually, the purified chromatin …

The existence of extracellular DNA in human plasma, also known as cell‐free DNA (cf DNA),
was first described in the 1940s. In recent years, there has been a resurgence of interest in …

MicroRNAs (miRNAs) are released from cells in association with proteins or microvesicles.
We previously reported that malignant transformation changes the assortment of released …

Improvement of ovarian cancer patient outcome requires well-characterized animal models
in which to evaluate novel therapeutics. Xenograft models are frequently used, but with little …

Cervical cancer remains one of the greatest killers of women worldwide. It is difficult to
foresee a dramatic increase in cure rate even with the most optimal combination of cytotoxic …

Nucleosomes, complexes of DNA and histone proteins, are released from dying and
stressed cells into the blood circulation. Concentrations of circulating nucleosomes in …

Liquid biopsies have emerged as a minimally invasive cancer detection and monitoring
method, which could identify cancer-related alterations in nucleosome or histone levels and …

Nucleosomes play a crucial role in regulating gene expression through their composition
and post-translational modifications. When cells die, intracellular endonucleases are …

Whether nucleic acids that circulate in blood have any patho-physiological functions in the
host have not been explored. We report here that far from being inert molecules, circulating …

In cancer, apoptotic processes occur both spontaneously and induced by antitumor
therapies. Qualitative and quantitative changes in cancer cell death along with proliferative …