Modulation of the biochemical composition of the tumour microenvironment is a new frontier
of cancer therapy. Several immunosuppressive mechanisms operate in the milieu of most …

Commonly, circulating tumor cells (CTCs) are described as source of metastasis in cancer
patients. However, in this process cancer cells of the primary tumor site need to survive the …

The interaction between circulating tumor cells and platelets is a key factor in cancer
metastasis. These interactions, driven by a variety of receptors, support circulating tumor …

The growing insights in the complex interactions between metastatic cancer-cells and
platelets have revealed that platelet tumor cell interactions in the blood stream are an …

The P2Y12 receptor is a key player in platelet activation and a major target for antithrombotic
drugs. The beneficial effects of P2Y12 receptor antagonists might, however, not be restricted …

The tumor microenvironment maintains a sufficient immunosuppressive state owing to the
existence of the immunosuppressive factors. The most prominent such factor is transforming …

Cancer tissues are not just simple masses of malignant cells, but rather complex and
heterogeneous collections of cellular and even non-cellular components, such as …

The invasion and metastasis of malignant tumors are major causes of death. The most
common metastases of cancer are lymphatic metastasis and hematogenous metastasis …

Although platelets are critically involved in thrombosis and hemostasis, experimental and
clinical evidence indicate that platelets promote tumor progression and metastasis through a …

Breast cancer is the most common cancer among women and is considered a developed
country disease. Moreover, is a heterogenous disease, existing different types and stages of …