The developing brain in utero and during the first years of life is highly vulnerable to
environmental influences. Experiences occurring during this period permanently modify …

Psychosocial maternal stress experienced during different vulnerable periods throughout
gestation is thought to increase the individual's risk to develop neuropsychiatric …

Recent studies have revealed robust metabolic changes during cell differentiation.
Mitochondria, the organelles where many vital metabolic reactions occur, may play an …

Significance: Skeletal muscle is a highly plastic tissue. Exercise evokes signaling pathways
that strongly modify myofiber metabolism and physiological and contractile properties of …

Progerin, a truncated unprocessed lamin A protein, causes tissue aging and degeneration.
In this study we explored the role of progerin in the pathogenesis of intervertebral disc …

Autophagy pathways are involved in the pathogenesis of some obesity related health
problems. As obesity is a nutrient sufficiency condition, autophagy process can be altered in …

Stress is an adaptive response to demands of the environment and thus essential for
survival. Exposure to stress during the first years of life has been shown to have profound …

Background: Preterm birth has a dramatic impact on polyunsaturated fatty acid exposures for
the developing brain. This study examined the association between postnatal fatty acid …

Mitochondrial dysfunction represents a common early pathological event in brain aging and
in neurodegenerative diseases, eg, in Alzheimer's (AD), Parkinson's (PD), and Huntington's …

The prevalence of psychiatric disorders which are characterized by cognitive decline is
increasing at an alarming rate and account for a significant proportion of the global disease …