The mechanism (s) of action of antioxidants: From scavenging reactive oxygen/nitrogen species to redox signaling and the generation of bioactive secondary …

A Hunyadi - Medicinal research reviews, 2019 - Wiley Online Library
Small molecule, dietary antioxidants exert a remarkably broad range of bioactivities, and
many of these can be explained by the influence of antioxidants on the redox homeostasis …

Modeling menopause: The utility of rodents in translational behavioral endocrinology research

SV Koebele, HA Bimonte-Nelson - Maturitas, 2016 - Elsevier
The human menopause transition and aging are each associated with an increase in a
variety of health risk factors including, but not limited to, cardiovascular disease …

Estrogens and phytoestrogens in body functions

I Ceccarelli, L Bioletti, S Peparini, E Solomita… - Neuroscience & …, 2022 - Elsevier
Estrogens are the hormones of reproduction in women as well as of many other important
functions in the male and female body. They undergo significant changes in the different …

Neuroactive steroids and Parkinson's disease: Review of human and animal studies

M Bourque, M Morissette, T Di Paolo - Neuroscience & Biobehavioral …, 2024 - Elsevier
The greater prevalence and incidence of Parkinson's disease (PD) in men suggest a
beneficial effect of sex hormones. Neuroactive steroids have neuroprotective activities thus …

Increased palmitoylation improves estrogen receptor alpha–dependent hippocampal synaptic deficits in a mouse model of synucleinopathy

TE Moors, S Li, TD McCaffery, GPH Ho… - Science …, 2023 - science.org
Parkinson's disease (PD) is characterized by conversion of soluble α-synuclein (αS) into
intraneuronal aggregates and degeneration of neurons and neuronal processes. Indications …

Gender differences in the neurobiology of anxiety: focus on adult hippocampal neurogenesis

AA Marques, MCN Bevilaqua… - Neural …, 2016 - Wiley Online Library
Although the literature reports a higher incidence of anxiety disorders in women, the majority
of basic research has focused on male rodents, thus resulting in a lack of knowledge on the …

Hormone replacement therapy: would it be possible to replicate a functional ovary?

S Agarwal, FA Alzahrani, A Ahmed - International journal of molecular …, 2018 - mdpi.com
Background: Throughout history, menopause has been regarded as a transition in a
woman's life. With the increase in life expectancy, women now spend more than a third of …

Estrogens, aging, and working memory

E Hampson - Current psychiatry reports, 2018 - Springer
Abstract Purpose of Review Working memory (WM) is a key process that is integral to many
complex cognitive tasks, and it declines significantly with advancing age. This review will …

Female sex and brain-selective estrogen benefit α-synuclein tetramerization and the PD-like motor syndrome in 3K transgenic mice

MM Rajsombath, AY Nam, M Ericsson… - Journal of …, 2019 - Soc Neuroscience
Many studies report a higher risk for Parkinson's disease (PD) and younger age of onset in
men. This, and the fact that the neuropathological process underlying PD symptoms may …

Brain selective estrogen treatment protects dopaminergic neurons and preserves behavioral function in MPTP-induced mouse model of Parkinson's disease

N Thadathil, J Xiao, R Hori, SE Alway… - Journal of Neuroimmune …, 2021 - Springer
Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic
neurons in the substantia nigra and loss of both motor and non-motor features. Several …