Prolonged low-grade inflammation or smoldering inflammation is a hallmark of cancer. Mast
cells form a heterogeneous population of immune cells with differences in their ultra …

Gastric cancer is diagnosed in nearly one million new patients each year and it remains the
second leading cause of cancer-related deaths worldwide. Although gastric cancer …

The use of various transgenic mouse models and analysis of human tumour biopsies has
shown that bone marrow-derived myeloid cells, such as macrophages, neutrophils …

Angiogenesis inhibitors are a new class of drugs, for which the general rules involving
conventional chemotherapy might not apply. The successful translation of angiogenesis …

The process of angiogenesis encompasses the growth and regression of capillary blood
vessels. Angiogenesis is finely regulated at the molecular and genetic levels, not unlike …

Although thalidomide (Thal) was initially used to treat multiple myeloma (MM) because of its
known antiangiogenic effects, the mechanism of its anti-MM activity is unclear. These studies …

Increased angiogenesis has recently been recognized in active multiple myeloma (MM).
Since vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) …

Angiogenesis is tightly regulated by pro‐and anti‐angiogenic factors. Secreting mast cells
are able to induce and enhance angiogenesis via multiple in part interacting pathways. They …

Accumulation of mast cells (MCs) in tumours was described by Ehrlich in his doctoral thesis.
Since this early account, ample evidence has been provided highlighting participation of …

Mast cells and basophils are key contributors to allergies and other inflammatory diseases
since they are the most prominent source of histamine as well as numerous additional …