[HTML][HTML] Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)
BO Roep, S Thomaidou, R van Tienhoven… - Nature Reviews …, 2021 - nature.com
Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …
[HTML][HTML] Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus
Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …
[HTML][HTML] Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection
Patients with coronavirus disease 2019 (COVID-19) are reported to have a greater
prevalence of hyperglycaemia. Cytokine release as a consequence of severe acute …
prevalence of hyperglycaemia. Cytokine release as a consequence of severe acute …
[HTML][HTML] A human pluripotent stem cell-based platform to study SARS-CoV-2 tropism and model virus infection in human cells and organoids
SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for
physiological models to study SARS-CoV-2 infection using human disease-relevant cells …
physiological models to study SARS-CoV-2 infection using human disease-relevant cells …
Type 1 diabetes
Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and
resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past …
resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past …
[HTML][HTML] SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas …
Increasing evidence demonstrated that the expression of Angiotensin I-Converting Enzyme
type 2 (ACE2) is a necessary step for SARS-CoV-2 infection permissiveness. In light of the …
type 2 (ACE2) is a necessary step for SARS-CoV-2 infection permissiveness. In light of the …
[HTML][HTML] Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial
L Krogvold, IM Mynarek, E Ponzi, FB Mørk… - Nature Medicine, 2023 - nature.com
Previous studies showed a low-grade enterovirus infection in the pancreatic islets of patients
with newly diagnosed type 1 diabetes (T1D). In the Diabetes Virus Detection (DiViD) …
with newly diagnosed type 1 diabetes (T1D). In the Diabetes Virus Detection (DiViD) …
Environmental risk factors for type 1 diabetes
M Rewers, J Ludvigsson - The Lancet, 2016 - thelancet.com
The incidence of type 1 diabetes has risen considerably in the past 30 years due to changes
in the environment that have been only partially identified. In this Series paper, we critically …
in the environment that have been only partially identified. In this Series paper, we critically …
The heterogeneous pathogenesis of type 1 diabetes mellitus
J Ilonen, J Lempainen, R Veijola - Nature Reviews Endocrinology, 2019 - nature.com
Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …
mediated by the immune system. Multiple genetic and environmental factors found in …
Bystander activation and autoimmunity
The interaction over time of genetic, epigenetic and environmental factors (ie, autoimmune
ecology) increases or decreases the liability an individual would have to develop an …
ecology) increases or decreases the liability an individual would have to develop an …