Over the past several decades, the possibility of joining together compounds in one crystal
lattice via well-defined intermolecular forces to shape drug-delivery relevant features, eg …

The degradation of drugs during melting was found to be one of the obstacles which restricts
the application of the thermal solvent-free (TSF) method as a simple and efficient technique …

We present the first polymorph interconversion study that uses solid-state dynamic covalent
chemistry (DCC). This system exhibits unexpected and rich behavior, including the …

In this work, a crystal engineering and thermodynamic based approach has been used
aiming at contributing to a deeper knowledge of lamotrigine multicomponent solid forms …

Apremilast (APR), an anti-psoriatic agent, easily forms isostructural cocrystals and solvates
with aromatic entities, often disobeying at the same time Kitaigorodsky's rule as to the …

Improving dissolution properties of active pharmaceutical ingredients (APIs) is a critical step
in drug development with the increasing occurrence of sparingly soluble APIs. Cocrystal …

The crystal landscape of a series of primary aromatic thioamides is described, displaying
similar characteristic intermolecular hydrogen-bonding interactions in the solid state to those …

The temperature dependent solubility of 18 organic compounds, of which some are active
pharmaceutical ingredients, was measured in 1, 4-dioxane, toluene and cyclopentyl methyl …

We prepared cocrystals of DL-2-Hydroxy-2-phenylacetic acid (D, L-H2ma) with the
pyridinecarboxamide isomers, picolinamide (pic) and isonicotinamide (inam). They were …

Eight novel cocrystals of picolinamide are reported in this study. Lattice energy calculations
may help us to understand their relative stabilities versus those of the individual …