Mast cells, which are granulocytes found in peripheral tissue, play a central role in
inflammatory and immediate allergic reactions. β‐Tryptase is a neutral serine protease and …

Mast cells (MCs) are traditionally thought of as a nuisance for its host, for example, by
causing many of the symptoms associated with allergic reactions. In addition, recent …

1 Mast cells participate in allergies, and also in immunity and inflammation by secreting
proinflammatory cytokines. 2 Flavonoids are naturally occurring polyphenolic plant …

Mast cells (MC s) play a central role in tissue homoeostasis, sensing the local environment
through numerous innate cell surface receptors. This enables them to respond rapidly to …

Historically, mast cells were known as a key cell type involved in type I hypersensitivity. Until
last two decades, this cell type was recognized to be widely involved in a number of non …

Since the seminal description implicating occupation of the Mas-related G protein-coupled
receptor X2 (MRGPRX2) in mast cell (MC) degranulation by drugs, many investigations …

In 1960, a trypsin‐like activity was found in mast cells [Glenner GG & Cohen LA (1960)
Nature185, 846–847] and this activity is now commonly referred to as 'tryptase'. Over the …

Proteases are the most abundant class of proteins produced by mast cells. Many of these
are stored in membrane-enclosed intracellular granules until liberated by degranulating …

SPINK5, encoding the putative multi-domain serine protease inhibitor LEKTI, was recently
identified as the defective gene in the severe autosomal recessive ichthyosiform skin …

Drug-induced anaphylaxis is a hyperacute reaction affecting multiple organs that can be of
fatal consequence. Its incidence is increasing, consistent with a global increased …