KRAS: the critical driver and therapeutic target for pancreatic cancer
RAS genes (HRAS, KRAS, and NRAS) comprise the most frequently mutated oncogene
family in human cancer. With the highest RAS mutation frequencies seen with the top three …
family in human cancer. With the highest RAS mutation frequencies seen with the top three …
BRAF—A tumour-agnostic drug target with lineage-specific dependencies
In June 2022, the FDA granted Accelerated Approval to the BRAF inhibitor dabrafenib in
combination with the MEK inhibitor trametinib for the treatment of adult and paediatric …
combination with the MEK inhibitor trametinib for the treatment of adult and paediatric …
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
With the continual evolution of new strains of severe acute respiratory syndrome coronavirus-
2 (SARS-CoV-2) that are more virulent, transmissible, and able to evade current vaccines …
2 (SARS-CoV-2) that are more virulent, transmissible, and able to evade current vaccines …
RAF inhibitors that evade paradoxical MAPK pathway activation
Oncogenic activation of BRAF fuels cancer growth by constitutively promoting RAS-
independent mitogen-activated protein kinase (MAPK) pathway signalling. Accordingly, RAF …
independent mitogen-activated protein kinase (MAPK) pathway signalling. Accordingly, RAF …
Diverse mechanisms of BRAF inhibitor resistance in melanoma identified in clinical and preclinical studies
SA Luebker, SA Koepsell - Frontiers in oncology, 2019 - frontiersin.org
BRAF inhibitor therapy may provide profound initial tumor regression in metastatic
melanoma with BRAF V600 mutations, but treatment resistance often leads to disease …
melanoma with BRAF V600 mutations, but treatment resistance often leads to disease …
PTPN11 is a central node in intrinsic and acquired resistance to targeted cancer drugs
A Prahallad, GJJE Heynen, G Germano, SM Willems… - Cell reports, 2015 - cell.com
Summary Most BRAF (V600E) mutant melanomas are sensitive to selective BRAF inhibitors,
but BRAF mutant colon cancers are intrinsically resistant to these drugs because of …
but BRAF mutant colon cancers are intrinsically resistant to these drugs because of …
Are there multiple cells of origin of Merkel cell carcinoma?
Merkel cell carcinoma (MCC) is a rare but lethal cancer with the highest case-by-case fatality
rate among all skin cancers. Eighty percent of cancers are associated with the Merkel cell …
rate among all skin cancers. Eighty percent of cancers are associated with the Merkel cell …
Targeting RAS-mutant cancers: is ERK the key?
The three RAS genes comprise the most frequently mutated oncogene family in cancer. With
significant and compelling evidence that continued function of mutant RAS is required for …
significant and compelling evidence that continued function of mutant RAS is required for …
DNA transposition at work
AB Hickman, F Dyda - Chemical reviews, 2016 - ACS Publications
DNA transposons are defined segments of DNA that are able to move from one genomic
location to another. Movement is facilitated by one or more proteins, called the transposase …
location to another. Movement is facilitated by one or more proteins, called the transposase …