A glass capillary-based nanopore (G-nanopore), due to its tapered tip, easy tunability in
orifice size, and especially its flexible surface modifications that can be tailored to effectively …

Microfluidic system, as a kind of miniature integrated operating platform, has been applied to
solid-state nanopore sensors after many years of experimental study. In the process of …

The three-dimensional structure of a protein plays an important role in protein dynamics in
the biological system of human. By now, it remains a challenge to characterize and quantify …

A challenge that remains to be solved in the high-throughput and low-cost nanopore DNA
sequencing is that DNA translocates through the nanopore too quickly to be sequenced with …

Discrimination of single nucleotides by a nanopore remains a challenge because of the
minor difference among the four types of single nucleotides. Here, the blockade currents …

As the single molecule detection tool, solid-state nanopores are being applied in more and
more fields, such as medicine controlled delivery, ion conductance microscopes …

Resistive pulse sensing with nanopores is expected to enable identification and analysis of
nanoscale objects in ionic solutions. However, there is currently no remarkable method to …

In this work, using a silicon nitride nanopore based device, we measure the binding
locations of RNA Polymerase (RNAP) on 48.5 kbp (16.5 μm) long λ DNA. To prevent the …

Single molecule detection based on nanopore technology is a very promising approach for
medical diagnostics, drug therapy and even DNA sequencing. Compared with other …

Foremost among the challenges facing single molecule sequencing of proteins by
nanopores is the lack of a universal method for driving proteins or peptides into nanopores …