The endoplasmic reticulum (ER) serves several essential cellular functions including protein
synthesis, protein folding, protein translocation, calcium homoeostasis and lipid …

Background: Cardiac arrhythmias represent a significant problem globally, leading to
cerebrovascular accidents, myocardial infarction, and sudden cardiac death. There is …

Ventricular arrhythmia is the leading cause of sudden cardiac death (SCD). Deranged
cardiac metabolism and abnormal redox state during cardiac diseases foment …

Background: Phospholamban (PLN) is a critical regulator of calcium cycling and contractility
in the heart. The loss of arginine at position 14 in PLN (R14del) is associated with dilated …

Cardiomyocyte pyroptosis and apoptosis play a vital role in the pathophysiology of several
cardiovascular diseases. Our recent study revealed that gasdermin D (GSDMD) can …

The endoplasmic reticulum (ER) is the site of production and folding of secreted, membrane
bound and some organelle targeted proteins. Accumulation of misfolded or unfolded …

Cardiovascular diseases lead the mortality and morbidity disease metrics worldwide. A
multitude of chemical base modifications in ribonucleic acids (RNAs) have been linked with …

The sarcoplasmic reticulum (SR) plays the key role in cardiac function as the major source of
Ca2+ that activates cardiomyocyte contractile machinery. Disturbances in finely-tuned SR …

Mutations of the cardiac sodium channel (Nav1. 5) can induce gain or loss of channel
function. Gain-of-function mutations can cause long QT syndrome type 3 and possibly atrial …

Calcium is an important second messenger in cardiac function. It is not only critical for the
excitationcontraction coupling and relaxation of the heart (Bers, 2002), but it is also …