The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

With the identification of huge amount of noncoding RNAs in recent years, the concept of
RNA localization has extended from traditional mRNA export to RNA export of mRNA and …

Oncogene-induced DNA replication stress (RS) and consequent pathogenic R-loop
formation are known to impede S phase progression. Nonetheless, cancer cells …

Long noncoding RNAs (lncRNAs) represent a multidimensional class of regulatory
molecules that are involved in many aspects of brain function. Emerging evidence indicates …

Mutations in the TERT promoter represent the genetic underpinnings of tumor cell
immortality. Beyond the two most common point mutations, which selectively recruit the ETS …

Background: Splicing factors are essential for nascent pre-mRNA processing and critical in
cancer progression, suggesting that proteins with splicing functions represent potential …

Summary lncRNA research is passing the stage of enumerating lncRNAs or recording
simplified on-off expression switches. Mechanistic analyses are starting to reveal …

Long noncoding RNAs (lncRNAs) are transcripts measuring> 200 bp in length and devoid of
protein-coding potential. LncRNAs exceed the number of protein-coding mRNAs and …

ABSTRACT PURPL is a p53-induced lncRNA that suppresses basal p53 levels. Here, we
investigated PURPL upon p53 activation in liver cancer cells, where it is expressed at …

A growing number of long noncoding RNAs (lncRNAs) have emerged as vital metabolic
regulators. However, most human lncRNAs are nonconserved and highly tissue specific …