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Monkeypox virus (MPXV) is closely related to the infamous variola (smallpox) virus, causing
a febrile rash illness in humans similar to but milder than smallpox. In the twentieth century …

In the last five years, the prevalence of monkeypox has been increasing both in the regions
considered endemic for the disease (West and Central Africa) and worldwide. Indeed, in …

Transmission electron microscopy (TEM) is the only imaging technique allowing the direct
visualization of viruses, due to its nanometer‐scale resolution. Between the 1960s and …

This review provides a brief history of the impacts that a human-specific Orthopoxvirus
(OPXV), Variola virus, had on mankind, recalls how critical vaccination was for the …

Since the eradication of smallpox, there have been increases in poxvirus infections and the
emergence of several novel poxviruses that can infect humans and domestic animals. In …

Orthopoxviruses (OPXVs) not only infect their natural hosts, but some OPXVs can also cause
disease in humans. Previously, we partially characterized an OPXV isolated from an 18-year …

The increasing frequency of monkeypox virus infections, new outbreaks of other zoonotic
orthopoxviruses and concern about the re-emergence of smallpox have prompted research …

Orthopoxviruses comprise several relevant pathogens, including the causative agent of
smallpox and monkeypox virus. Analysis of orthopoxvirus genome evolution mainly focused …

Poxviruses as a group have variable levels of host ranges and virulence. For example,
smallpox, which is caused by the variola virus, only infects humans with fatal outcomes …