Leucine-rich repeats (LRRs) are 20–29-residue sequence motifs present in a number of
proteins with diverse functions. The primary function of these motifs appears to be to provide …

The nuclear import of proteins through nuclear pore complexes (NPCs) illustrates how a
complex biological function can be generated by a spatially and temporally organized cycle …

SUMMARY A defining characteristic of eukaryotic cells is the possession of a nuclear
envelope. Transport of macromolecules between the nuclear and cytoplasmic compartments …

E2 enzymes catalyze attachment of ubiquitin and ubiquitin-like proteins to lysine residues
directly or through E3-mediated reactions. The small ubiquitin-like modifier SUMO regulates …

In eukaryotic cells, segregation of DNA replication and RNA biogenesis in the nucleus and
protein synthesis in the cytoplasm poses the requirement of transporting thousands of …

Abstract Background Toll-like receptors (TLRs) play a central role in innate immunity. TLRs
are membrane glycoproteins and contain leucine rich repeat (LRR) motif in the ectodomain …

The genus Trichoderma contains fungi with high relevance for humans, with applications in
enzyme production for plant cell wall degradation and use in biocontrol. Here, we provide a …

Typical members of the Ras superfamily of small monomeric GTP-binding proteins function
as regulators of diverse processes by cycling between biologically active GTP-and inactive …

Transport receptors of the Importin β family shuttle between the nucleus and cytoplasm and
mediate transport of macromolecules through nuclear pore complexes. They interact …

Nuclear export is an essential eukaryotic activity. It proceeds through nuclear pore
complexes (NPCs) and is mediated by soluble receptors that shuttle between nucleus and …