Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids

AR Mazo, S Allison-Logan, F Karimi… - Chemical society …, 2020 - pubs.rsc.org
Polypeptides have attracted considerable attention in recent decades due to their inherent
biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with …

Biodegradable stimuli-responsive polypeptide materials prepared by ring opening polymerization

Y Shen, X Fu, W Fu, Z Li - Chemical Society Reviews, 2015 - pubs.rsc.org
The stimuli-responsive polypeptides have drawn extensive attention because of their
promising applications in biotechnology considering their biocompatibility, biodegradability …

Secondary structures of synthetic polypeptide polymers

C Bonduelle - Polymer Chemistry, 2018 - pubs.rsc.org
Synthetic peptide-based polymers represent a unique class of macromolecules able to
mimic the properties of natural proteins in materials sciences since (1) they present the …

Thermoresponsive polymers: from natural proteins to amino acid based Polymer synthesis

M Badreldin, P Salas-Ambrosio, E Garanger… - Progress in Polymer …, 2023 - Elsevier
In polymer science, thermoresponsiveness refers to macromolecular systems that display a
marked and discontinuous change in their physical properties with temperature. Such smart …

α-Amino acid N-carboxyanhydride (NCA)-derived synthetic polypeptides for nucleic acids delivery

Y Liu, L Yin - Advanced Drug Delivery Reviews, 2021 - Elsevier
In recent years, gene therapy has come into the spotlight for the prevention and treatment of
a wide range of diseases. Polypeptides have been widely used in mediating nucleic acid …

Injectable hydrogels for cancer therapy over the last decade

G Cirillo, UG Spizzirri, M Curcio, FP Nicoletta, F Iemma - Pharmaceutics, 2019 - mdpi.com
The interest in injectable hydrogels for cancer treatment has been significantly growing over
the last decade, due to the availability of a wide range of starting polymer structures with …

pH‐and temperature‐responsive hydrogels based on tertiary amine‐modified polypeptides for stimuli‐responsive drug delivery

Z Lin, J Ding, X Chen, C He - Chemistry–An Asian Journal, 2023 - Wiley Online Library
Abstract pH‐and temperature‐responsive hydrogels have attracted considerable attention
due to their responsiveness to dual physiologically‐relevant stimuli. In this study, we …

Smart polymersomes and hydrogels from polypeptide-based polymer systems through α-amino acid N-carboxyanhydride ring-opening polymerization. From chemistry …

E Liarou, S Varlas, D Skoulas, C Tsimblouli… - Progress in Polymer …, 2018 - Elsevier
The synthesis of smart stimuli-responsive polymeric materials for nanomedicine applications
has attracted the interest of a large number of scientists that focuses on the effective …

Advances and Biomedical Applications of Polypeptide Hydrogels Derived from α‐Amino Acid N‐Carboxyanhydride (NCA) Polymerizations

X Zhou, Z Li - Advanced healthcare materials, 2018 - Wiley Online Library
Polypeptide hydrogels, having the ability to mimic certain properties of natural, native
extracellular matrix components, are being actively designed and described for various …

Polypeptide-based systems: From synthesis to application in drug delivery

M Stepanova, A Nikiforov, T Tennikova… - Pharmaceutics, 2023 - mdpi.com
Synthetic polypeptides are biocompatible and biodegradable macromolecules whose
composition and architecture can vary over a wide range. Their unique ability to form …