The Growth Arrest and DNA Damage-inducible 45 (GADD45) proteins have been implicated
in regulation of many cellular functions including DNA repair, cell cycle control, senescence …

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in the adult
population and it carries a dismal prognosis. Inefficient drug delivery across the blood brain …

The “holy grail” of cancer therapy is to identify and exploit genetic elements and signal
transduction pathways capable of selectively destroying tumor cells without eliciting harmful …

The mda-7 gene (approved gene symbol IL24) is a novel tumor suppressor gene with tumor-
apoptotic and immune-activating properties. We completed a Phase I dose-escalation …

First identified almost two decades ago as a novel gene differentially expressed in human
melanoma cells induced to terminally differentiate, MDA-7/IL-24 has since shown great …

“Differentiation therapy” provides a unique and potentially effective, less toxic treatment
paradigm for cancer. Moreover, combining “differentiation therapy” with molecular …

An obstacle to effective gene-based cancer therapies is the limited number of cancer-
specific growth suppressing and apoptosis-inducing genes. Using a differentiation induction …

Apoptosis and autophagy play seminal roles in maintaining organ homeostasis. Apoptosis
represents canonical type I programmed cell death. Autophagy is viewed as pro-survival …

Melanoma differentiation associated gene-7 (mda-7) was cloned using subtraction
hybridization from terminally differentiated human melanoma cells. Based on structural and …

A noteworthy aspect of melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-
24) as a cancer therapeutic is its ability to selectively kill cancer cells without harming normal …