Insulin is a major endocrine hormone also involved in the regulation of energy and lipid
metabolism via the activation of an intracellular signaling cascade involving the insulin …

Excessive caloric intake without a rise in energy expenditure promotes adipocyte
hyperplasia and adiposity. The rise in adipocyte number is triggered by signaling factors that …

Cancer-associated cachexia is a multi-organ weight loss syndrome, especially with a
wasting disorder of adipose tissue and skeletal muscle. Small extracellular vesicles (sEVs) …

Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disorder in
women of reproductive age. The diagnostic criteria include two out of three features …

Methods for assessment, eg., anthropometric indicators and imaging techniques, of several
phenotypes of human obesity, with special reference to abdominal fat content, have been …

Following the discovery of leptin in 1994, the scientific and clinical communities have held
great hope that manipulation of the leptin axis may lead to the successful treatment of …

We have studied the effect of fasting on serum leptin levels in normal volunteers. Five
normal-weight (BMI< 28, 2 males/3 females) and five obese subjects (BMI> 28, 2 males/3 …

IGF-I is expressed in virtually every tissue of the body, but with much higher expression in
the liver than in any other tissue. Studies using mice with liver-specific IGF-I knockout have …

The prevalence of obesity has markedly increased over the past two decades, especially in
the industrialized countries. While the impact of excess body weight on the development of …

Leptin (from the Greek leptos= thin) was identified only 3 years ago. It has attracted huge
attention both scentifically, with more than 600 publications, and in the media, where this …