Fluorescent lipophilic dyes, such as DiI, stain cellular membranes and are used extensively
for retrograde/anterograde labeling of neurons as well as for marking the position of …

Vesicle pool properties are known determinants of synaptic efficacy, but their potential role
as modifiable substrates in forms of Hebbian plasticity is still unclear. Here, we investigate …

Alzheimer's disease is linked to increased levels of amyloid beta (Aβ) in the brain, but the
mechanisms underlying neuronal dysfunction and neurodegeneration remain enigmatic …

Efficient recycling of synaptic vesicles is thought to be critical for sustained information
transfer at central terminals. However, the specific contribution that retrieved vesicles make …

Over the course of the last few decades it has become clear that many neurodevelopmental
and neurodegenerative disorders have a synaptic defect, which contributes to pathogenicity …

Regulated secretion is a fundamental cellular process that serves diverse functions in
neurobiology, endocrinology, immunology, and numerous other aspects of animal …

Neuronal hyperexcitability often results from an unbalance between excitatory and inhibitory
neurotransmission, but the synaptic alterations leading to enhanced seizure propensity are …

Here, we describe a cost-effective setup for targeted photoconversion of fluorescent signals
into electron dense ones. This approach has offered invaluable insights in the morphology …

Changes in postsynaptic neuronal excitability have been well characterised in epilepsy, but
presynaptic contributions are less understood. Hyperexcitability and seizures in a mouse …

Neuronal networks' hyperexcitability often results from an unbalance between excitatory and
inhibitory neurotransmission; however, underlying synaptic alterations leading to this …