Monoterpene indole alkaloids (MIAs) make up a highly bioactive class of metabolites
produced by a range of tropical and subtropical plants. The corynanthe-type MIAs are a …

The search for drugs with anorectic activity, acting within the adrenergic system has attracted
the interest of researchers. Partial α2-adrenoceptor agonists might offer the potential for …

Selective NPY-Y5 antagonists are known to reduce NPY-evoked increase of food intake
under free feeding conditions and drug-reinforced operant responding in rodents suggesting …

Drugs that act on α-adrenoceptors may contain morpholine and pyrimidinone heterocycles.
The aim of this study was to synthesize a series of pyrimidinones (S6a-e and S8) and …

The spontaneous and event-related firing activity of the medial prefrontal cortex (mPFC)
pyramidal neurons are modulated mainly by glutamatergic inputs and GABAergic afferents …

Pharmacological and functional data suggest the existence of uridine (Urd) receptors in the
central nervous system (CNS). In the present study, simultaneous extracellular single unit …

Microiontophoresis combined with extracellular spike recording is an excellent method for
investigating local neuropharmacological effects under in vivo conditions. However, its …

In this study we provide evidence that animals of the same population, although identical in
age and sex, have individual reactions to the prefrontal modulation of adrenoceptors. We …

Applying electrophysiological recording techniques as considerable technological progress
in neurophysiological methods has provided the major advance in the neuroscience …

Previously, we reported that antinociceptive synergism of a 5‐HT3/α2‐adrenoceptor ligand
MD‐354 (m‐chlorophenylguanidine) and clonidine combination occurs, in part, through a 5 …