▪ Abstract Intensive studies of three proteins—Presenilin, Notch, and the amyloid precursor
protein (APP)—have led to the recognition of a direct intersection between early …

Vestibular epithelia of the inner ear detect head motions over a wide range of amplitudes
and frequencies. In mammals, afferent nerve fibers from central and peripheral zones of …

Reactive oxygen species (ROS) play a major role in drug-, noise-, and age-dependent
hearing loss, but the source of ROS in the inner ear remains largely unknown. Herein, we …

Cranial placodes are specialized regions of the ectoderm, which give rise to various sensory
ganglia and contribute to the pituitary gland and sensory organs of the vertebrate head …

The homeobox Six genes, homologues to Drosophila sine oculis (so) gene, are expressed
in multiple organs during mammalian development. However, their roles during auditory …

The inner ear is one of the most morphologically elaborate tissues in vertebrates, containing
a group of mechanosensitive sensory organs that mediate hearing and balance. These …

The inner ear is a structurally complex vertebrate organ built to encode sound, motion, and
orientation in space. Given its complexity, it is not surprising that inner ear dysfunction is a …

The inner ear is partitioned along its dorsal/ventral axis into vestibular and auditory organs,
respectively. Gene expression studies suggest that this subdivision occurs within the otic …

Historically, the neuron has been the conceptual focus for almost all of neuroscience
research. In recent years, however, the concept of the neurovascular unit has emerged as a …

Regeneration of sensory hair cells in the mature avian inner ear was first described just over
20 years ago. Since then, it has been shown that many other non-mammalian species either …