Pharmaceutical drugs and natural therapeutic products for the treatment of type 2 diabetes mellitus

J Blahova, M Martiniakova, M Babikova, V Kovacova… - Pharmaceuticals, 2021 - mdpi.com
Type 2 diabetes mellitus (T2DM) is the most widespread form of diabetes, characterized by
chronic hyperglycaemia, insulin resistance, and inefficient insulin secretion and action …

Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms

L Xu, Y Li, Y Dai, J Peng - Pharmacological research, 2018 - Elsevier
Epidemiological studies have implied that diabetes mellitus (DM) will become an epidemic
accompany with metabolic and endocrine disorders worldwide. Most of DM patients are …

Honey bee products: preclinical and clinical studies of their anti-inflammatory and immunomodulatory properties

HR El-Seedi, N Eid, AA Abd El-Wahed, ME Rateb… - Frontiers in …, 2022 - frontiersin.org
Inflammation is a defense process triggered when the body faces assaults from pathogens,
toxic substances, microbial infections, or when tissue is damaged. Immune and inflammatory …

[HTML][HTML] New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

HS Kim, MJ Quon, J Kim - Redox biology, 2014 - Elsevier
Green tea is rich in polyphenol flavonoids including catechins. Epigallocatechin 3-gallate
(EGCG) is the most abundant and potent green tea catechin. EGCG has been extensively …

Propolis: a complex natural product with a plethora of biological activities that can be explored for drug development

R Silva-Carvalho, F Baltazar… - Evidence‐Based …, 2015 - Wiley Online Library
The health industry has always used natural products as a rich, promising, and alternative
source of drugs that are used in the health system. Propolis, a natural resinous product …

Molecular and cellular mechanisms of propolis and its polyphenolic compounds against cancer

N Oršolić, M Jazvinšćak Jembrek - International journal of molecular …, 2022 - mdpi.com
In recent years, interest in natural products such as alternative sources of pharmaceuticals
for numerous chronic diseases, including tumors, has been renewed. Propolis, a natural …

Efficacy of caffeic acid on diabetes and its complications in the mouse

N Oršolić, D Sirovina, D Odeh, G Gajski, V Balta, L Šver… - Molecules, 2021 - mdpi.com
Diabetic dyslipidemia and hyperglycemia contribute to excessive reactive oxygen species
(ROS) production, leading to deleterious complications, such as nephropathy …

GABA receptors: pharmacological potential and pitfalls

M Jazvinscak Jembrek, J Vlainic - Current pharmaceutical …, 2015 - ingentaconnect.com
Gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter in the mammalian
central nervous system, plays a key role in the regulation of neuronal transmission …

Antioxidant capacity and major polyphenol composition of teas as affected by geographical location, plantation elevation and leaf grade

C Zhang, CLC Suen, C Yang, SY Quek - Food Chemistry, 2018 - Elsevier
Tea polyphenols have been a topic of discussion due to their health benefits. Nevertheless,
detailed studies on the antioxidant capacity and polyphenol contents of teas in relation to …

Epigallocatechin-3-gallate protects against diabetic cardiomyopathy through modulating the cardiometabolic risk factors, oxidative stress, inflammation, cell death and …

AI Othman, MR El-Sawi, MA El-Missiry… - Biomedicine & …, 2017 - Elsevier
The potential protective effect of epigallocatechin-3-gallate (EGCG) on type 2 diabetes-
induced heart injury was investigated. A rat model of diabetes was achieved by injection of …