The tectum/superior colliculus as the vertebrate solution for spatial sensory integration and action

T Isa, E Marquez-Legorreta, S Grillner, EK Scott - Current Biology, 2021 - cell.com
The superior colliculus, or tectum in the case of non-mammalian vertebrates, is a part of the
brain that registers events in the surrounding space, often through vision and hearing, but …

Retinal ganglion cells—diversity of cell types and clinical relevance

US Kim, OA Mahroo, JD Mollon… - Frontiers in neurology, 2021 - frontiersin.org
Retinal ganglion cells (RGCs) are the bridging neurons that connect the retinal input to the
visual processing centres within the central nervous system. There is a remarkable diversity …

Molecular classification and comparative taxonomics of foveal and peripheral cells in primate retina

YR Peng, K Shekhar, W Yan, D Herrmann… - Cell, 2019 - cell.com
High-acuity vision in primates, including humans, is mediated by a small central retinal
region called the fovea. As more accessible organisms lack a fovea, its specialized function …

Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes

BA Rheaume, A Jereen, M Bolisetty, MS Sajid… - Nature …, 2018 - nature.com
Retinal ganglion cells (RGCs) convey the major output of information collected from the eye
to the brain. Thirty subtypes of RGCs have been identified to date. Here, we analyze 6225 …

Mouse retinal cell atlas: molecular identification of over sixty amacrine cell types

W Yan, MA Laboulaye, NM Tran… - Journal of …, 2020 - Soc Neuroscience
Amacrine cells (ACs) are a diverse class of interneurons that modulate input from
photoreceptors to retinal ganglion cells (RGCs), rendering each RGC type selectively …

Evolution of neuronal cell classes and types in the vertebrate retina

J Hahn, A Monavarfeshani, M Qiao, AH Kao, Y Kölsch… - Nature, 2023 - nature.com
The basic plan of the retina is conserved across vertebrates, yet species differ profoundly in
their visual needs. Retinal cell types may have evolved to accommodate these varied needs …

Novel insights from a multiomics dissection of the Hayflick limit

M Chan, H Yuan, I Soifer, TM Maile, RY Wang… - Elife, 2022 - elifesciences.org
The process wherein dividing cells exhaust proliferative capacity and enter into replicative
senescence has become a prominent model for cellular aging in vitro. Despite decades of …

Droplet-based method and apparatus for composite single-cell nucleic acid analysis

A Regev, EZ Macosko, SA McCarroll… - US Patent …, 2023 - Google Patents
US11597964B2 - Droplet-based method and apparatus for composite single-cell nucleic acid
analysis - Google Patents US11597964B2 - Droplet-based method and apparatus for composite …

A cell atlas of the chick retina based on single-cell transcriptomics

M Yamagata, W Yan, JR Sanes - Elife, 2021 - elifesciences.org
Retinal structure and function have been studied in many vertebrate orders, but molecular
characterization has been largely confined to mammals. We used single-cell RNA …

Thrombospondin-1 mediates axon regeneration in retinal ganglion cells

ER Bray, BJ Yungher, K Levay, M Ribeiro… - Neuron, 2019 - cell.com
Neuronal subtypes show diverse injury responses, but the molecular underpinnings remain
elusive. Using transgenic mice that allow reliable visualization of axonal fate, we …