Alternative splicing is a substantial contributor to the high complexity of transcriptomes of
multicellular eukaryotes. In this Review, we discuss the accumulated evidence that most of …

Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …

The plant circadian clock coordinates the responses to multiple and often simultaneous
environmental challenges that the sessile plant cannot avoid. These responses must be …

Alternative splicing was discovered simultaneously with splicing over three decades ago.
Since then, an enormous body of evidence has demonstrated the prevalence of alternative …

High-throughput sequencing for transcript profiling in plants has revealed that alternative
splicing (AS) affects a much higher proportion of the transcriptome than was previously …

Circadian clocks are endogenous timekeeping networks that allow organisms to align their
physiology with their changing environment and to perform biological processes at the most …

Alternative splicing generates multiple transcript and protein isoforms from the same gene
and thus is important in gene expression regulation. To date, RNA-sequencing (RNA-seq) is …

More than 60% of intron-containing genes undergo alternative splicing (AS) in plants. This
number will increase when AS in different tissues, developmental stages, and environmental …

Circadian clocks integrate environmental signals with internal cues to coordinate diverse
physiological outputs so that they occur at the most appropriate season or time of day …

Glioblastoma (GBM) is a devastating malignancy with few therapeutic options. We identify
PRMT5 in an in vivo GBM shRNA screen and show that PRMT5 knockdown or inhibition …