Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver
disease worldwide and is strongly associated with the presence of oxidative stress …
disease worldwide and is strongly associated with the presence of oxidative stress …
NAD+ homeostasis in health and disease
The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …
[HTML][HTML] Investigating mitochondrial redox state using NADH and NADPH autofluorescence
TS Blacker, MR Duchen - Free Radical Biology and Medicine, 2016 - Elsevier
The redox states of the NAD and NADP pyridine nucleotide pools play critical roles in
defining the activity of energy producing pathways, in driving oxidative stress and in …
defining the activity of energy producing pathways, in driving oxidative stress and in …
Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage
AM Cameron, A Castoldi, DE Sanin… - Nature …, 2019 - nature.com
The adoption of Warburg metabolism is critical for the activation of macrophages in
response to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase …
response to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase …
Defining the consequences of genetic variation on a proteome-wide scale
Genetic variation modulates protein expression through both transcriptional and post-
transcriptional mechanisms. To characterize the consequences of natural genetic diversity …
transcriptional mechanisms. To characterize the consequences of natural genetic diversity …
[HTML][HTML] Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors
EE Brown, AJ DeWeerd, CJ Ildefonso, AS Lewin… - Redox biology, 2019 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of vision loss in the western
world. Recent evidence suggests that RPE and photoreceptors have an interconnected …
world. Recent evidence suggests that RPE and photoreceptors have an interconnected …
Hyperglycemia-driven inhibition of AMP-activated protein kinase α2 induces diabetic cardiomyopathy by promoting mitochondria-associated endoplasmic reticulum …
Background: Fundc1 (FUN14 domain containing 1), an outer mitochondrial membrane
protein, is important for mitophagy and mitochondria-associated endoplasmic reticulum …
protein, is important for mitophagy and mitochondria-associated endoplasmic reticulum …
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism.
The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide …
The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide …
In vitro and in vivo models of non-alcoholic fatty liver disease: a critical appraisal
PA Soret, J Magusto, C Housset… - Journal of clinical medicine, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD), including non-alcoholic fatty liver (NAFL) and non-
alcoholic steatohepatitis (NASH), represents the hepatic manifestation of obesity and …
alcoholic steatohepatitis (NASH), represents the hepatic manifestation of obesity and …
Attention to background strain is essential for metabolic research: C57BL/6 and the international knockout mouse consortium
DA Fontaine, DB Davis - Diabetes, 2016 - Am Diabetes Assoc
The International Knockout Mouse Consortium (IKMC) introduces its targeted constructs into
C57BL/6N embryonic stem cells. However, breeding with a Cre-recombinase and/or Flp …
C57BL/6N embryonic stem cells. However, breeding with a Cre-recombinase and/or Flp …