[HTML][HTML] Multifunctional opioid-derived hybrids in neuropathic pain: Preclinical evidence, ideas and challenges
J Starnowska-Sokół, B Przewłocka - Molecules, 2020 - mdpi.com
When the first-and second-line therapeutics used to treat neuropathic pain (NP) fail to
induce efficient analgesia—which is estimated to relate to more than half of the patients …
induce efficient analgesia—which is estimated to relate to more than half of the patients …
[HTML][HTML] Artesunate alleviates paclitaxel-induced neuropathic pain in mice by decreasing metabotropic glutamate receptor 5 activity and neuroinflammation in primary …
Y Li, J Kang, Y Xu, N Li, Y Jiao, C Wang… - Frontiers in Molecular …, 2022 - frontiersin.org
Experimental studies on the pathogenetic process of paclitaxel-induced neuropathic pain
(PINP) have been initially carried out, but PINP still has no effective therapy. Recently …
(PINP) have been initially carried out, but PINP still has no effective therapy. Recently …
[HTML][HTML] Opioids, Stress and Addiction: From Stress-Induced Analgesia to Opioid Heterodimers with Extraordinary Analgesic Efficacy and Without the Side Effects of …
Abstract The Special Issue on Stress and Addiction is concerned with interrelationships
between environmental stimuli such as stress and endogenous opioid systems that lead to …
between environmental stimuli such as stress and endogenous opioid systems that lead to …
MMG22 potently blocks hyperalgesia in cisplatin-treated mice
G Cataldo, MM Lunzer, E Akgün, HL Wong… - Neuroscience, 2023 - Elsevier
MMG22 is a bivalent ligand containing MOR agonist and mGluR5 antagonist
pharmacophores connected by a 22-atom linker. Intrathecal (it) administration of MMG22 to …
pharmacophores connected by a 22-atom linker. Intrathecal (it) administration of MMG22 to …
Bivalent Ligand MMG22 Reduces Bone Cancer Pain without Tolerance or Sedation
SS Shueb - 2022 - search.proquest.com
Pain is among the most common symptoms in cancer and approximately 90% of patients
experience end-stage cancer pain. The management of cancer pain is challenging due to …
experience end-stage cancer pain. The management of cancer pain is challenging due to …