The generation of B-lymphocytes from hematopoietic stem cells is controlled by multiple
transcription factors regulating distinct developmental aspects. Ikaros and PU. 1 act in …

▪ Abstract Natural killer (NK) cells play important roles in immunological processes, including
early defense against viral infections. This review provides an overview of the dynamic in …

Natural killer (NK) cells play critical roles defending against tumors and pathogens. We
show that mice lacking both transcription factors Eomesodermin (Eomes) and T-bet failed to …

Natural killer (NK) and CD1d-restricted Vα14i natural killer T (NKT) cells play a critical early
role in host defense. Here we show that mice with a targeted deletion of T-bet, a T-box …

Natural killer (NK) cells are a subset of lymphocytes crucial for innate immunity and
modification of adaptive immune responses. In contrast to commitment to the T cell or B cell …

The PU. 1 transcription factor is a key regulator of hematopoietic development, but its role at
each hematopoietic stage remains unclear. In particular, the expression of PU. 1 in …

We know how B and T cells develop, what they'see'and the receptors they'see with'. By
contrast, and despite an unprecedented increase in the number of receptors and ligands …

Prospective isolation of hematopoietic stem and progenitor cells has identified the lineal
relationships among all blood-cell types and has allowed their developmental mechanisms …

Human natural killer (NK) cells have distinct functions as NK tolerant, NK cytotoxic and NK
regulatory cells and can be divided into different subsets based on the relative expression of …

The Id2 transcriptional repressor is essential for development of natural killer (NK) cells,
lymphoid tissue–inducing (LTi) cells, and secondary lymphoid tissues. Id2 was proposed to …