The role of IL‐17 and related cytokines in inflammatory autoimmune diseases
T Kuwabara, F Ishikawa, M Kondo… - Mediators of …, 2017 - Wiley Online Library
Interleukin‐17 (IL‐17) induces the production of granulocyte colony‐stimulating factor (G‐
CSF) and chemokines such as CXCL1 and CXCL2 and is a cytokine that acts as an …
CSF) and chemokines such as CXCL1 and CXCL2 and is a cytokine that acts as an …
Interleukin 17 is a chief orchestrator of immunity
M Veldhoen - Nature immunology, 2017 - nature.com
Increased understanding of the biology of interleukin 17 (IL-17) has revealed that this
cytokine is a central player in immunity at the sites most exposed to microorganisms …
cytokine is a central player in immunity at the sites most exposed to microorganisms …
T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
Abstract CD4+ T helper (Th) cells are critical for proper immune cell homeostasis and host
defense, but are also major contributors to pathology of autoimmune and inflammatory …
defense, but are also major contributors to pathology of autoimmune and inflammatory …
IL‐17 and IL‐22 in immunity: Driving protection and pathology
K Eyerich, V Dimartino, A Cavani - European journal of …, 2017 - Wiley Online Library
IL‐17 and IL‐22 are tissue‐signaling cytokines that favor protection and regeneration of
barrier organs such as the skin, lung, and gastrointestinal system. Both cytokines share …
barrier organs such as the skin, lung, and gastrointestinal system. Both cytokines share …
The IL-23–IL-17 axis in inflammatory arthritis
E Lubberts - Nature Reviews Rheumatology, 2015 - nature.com
The discovery that the IL-23–IL-17 immune pathway is involved in many models of
autoimmune disease has changed the concept of the role of T-helper cell subsets in the …
autoimmune disease has changed the concept of the role of T-helper cell subsets in the …
Therapeutic opportunities of the IL-22–IL-22R1 system
R Sabat, W Ouyang, K Wolk - Nature reviews Drug discovery, 2014 - nature.com
Abstract Interleukin-22 (IL-22) is a key effector molecule that is produced by activated T cells,
including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate …
including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate …
Functional specialization of interleukin-17 family members
Y Iwakura, H Ishigame, S Saijo, S Nakae - Immunity, 2011 - cell.com
Interleukin-17A (IL-17A) is the signature cytokine of the recently identified T helper 17 (Th17)
cell subset. IL-17 has six family members (IL-17A to IL-17F). Although IL-17A and IL-17F …
cell subset. IL-17 has six family members (IL-17A to IL-17F). Although IL-17A and IL-17F …
Regulation and functions of the IL-10 family of cytokines in inflammation and disease
The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-
26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family …
26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family …
Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
GF Sonnenberg, LA Fouser, D Artis - Nature immunology, 2011 - nature.com
The maintenance of barrier function at exposed surfaces of the mammalian body is essential
for limiting exposure to environmental stimuli, preventing systemic dissemination of …
for limiting exposure to environmental stimuli, preventing systemic dissemination of …
The IL-20 subfamily of cytokines—from host defence to tissue homeostasis
Abstract The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24
and IL-26. These cytokines are all members of the larger IL-10 family, but have been …
and IL-26. These cytokines are all members of the larger IL-10 family, but have been …