Overexpression of the epidermal growth factor receptor (EGFR) has been linked to several
human cancers, including esophageal cancer, pancreatic cancer, anal cancer, breast …

Breast cancer, as one of the most common invasive malignancies and the leading cause of
cancer‐related deaths in women globally, poses a significant challenge in the world health …

A small set of indole-based derivatives, IV and Va–I, was designed and synthesized.
Compounds Va–i demonstrated promising antiproliferative activity, with GI50 values ranging …

The investigation of novel EGFR and BRAFV600E dual inhibitors is intended to serve as
targeted cancer treatment. Two sets of purine/pteridine-based derivatives were designed …

Abstract A novel series of 1, 2, 3-triazole/1, 2, 4-oxadiazole hybrids (7a–o) was developed
as dual inhibitors of EGFR/VEGFR-2. Compounds 7a–o were evaluated as antiproliferative …

Abstract In this study, 12 novel 2‐((1‐(4‐(1H‐imidazol‐1‐yl) phenyl) ethylidene)
hydrazineylidene)‐3‐ethyl‐4‐(substitutephenyl)‐2, 3‐dihydrothiazole derivatives were …

2, 3, 4-trisubstituted thiazoles 3a–i, having a methyl group in position four, were synthesized
by the reaction of 1, 4-disubstituted thiosemicarbazides with chloroacetone in ethyl …

A new series of 1, 3, 4-thiadiazin-3-ium bromide derivatives 9a–g were prepared as a six-
member ring by interactions between 4-substituted thiosemicarbazides 8a–e and α-halo …

The current study focuses on developing a single molecule that acts as an antiproliferative
agent with dual or multi-targeted action, reducing drug resistance and adverse effects. A …

New quinoline-based derivatives 3a-d and 4a-d have been designed and synthesized as
promising antiproliferative candidates. The designed compounds were tested for their …