Intercellular signaling molecules, known as morphogens, act at a long range in developing
tissues to provide spatial information and control properties such as cell fate and tissue …

Cells within developing tissues rely on morphogens to assess positional information.
Passive diffusion is the most parsimonious transport model for long-range morphogen …

▪ Abstract Tight control of cell-cell communication is essential for the generation of a
normally patterned embryo. A critical mediator of key cell-cell signaling events during …

Cell proliferation, cell death, and pattern formation are coordinated in animal development.
Although many proteins that control cell proliferation and apoptosis have been identified, the …

Haematopoietic stem cells (HSCs) have the ability to renew themselves and to give rise to
all lineages of the blood; however, the signals that regulate HSC self-renewal remain …

▪ Abstract Wnt genes encode a large family of secreted, cysteine-rich proteins that play key
roles as intercellular signaling molecules in development. Genetic studies in Drosophila and …

Morphogens are long-range signaling molecules that pattern developing tissues in a
concentration-dependent manner. The graded activity of morphogens within tissues …

Wnt signaling through the canonical β-catenin pathway plays essential roles in development
and disease. L ow-density-lipoprotein receptor-r elated p roteins 5 and 6 (Lrp5 and Lrp6) in …

In many contexts, self-renewal and differentiation of stem cells are influenced by signals
from their environment, constituting a niche. It is postulated that stem cells compete for local …

We investigated the potential of double-stranded RNA to interfere with the function of genes
in Drosophila. Injection of dsRNA into embryos resulted in potent and specific interference of …