Age-related macular degeneration (AMD) and glaucoma are degenerative conditions of the
retina and a significant cause of irreversible blindness in developed countries. Alzheimer's …

Heparin is the earliest and most widely used anticoagulant and antithrombotic drug that is
still used in a variety of clinical indications. Since it was discovered in 1916, after more than …

During the last few years, the autophagy lysosomal system is emerging as a central cellular
pathway with roles in survival, acting as a housekeeper and stress response mechanism …

Ferritin, one of the key regulators of iron homeostasis, is widely present throughout almost
all species. The vertebrate ferritin family, which originates from a single gene in the ancestral …

Exosomes, nanosized extracellular vesicles with a size of 30–150nm, contain many
biological materials, such as messenger RNA (mRNA), microRNA (miRNA), proteins, and …

Abstract α-Synuclein (α-Syn) is implicated in Parkinson's disease (PD), a neuromotor
disorder with prominent visual symptoms. The underlying cause of motor dysfunction has …

The concentration of iron is tightly regulated, making it an essential element. Various cellular
processes in the body rely on iron, such as oxygen sensing, oxygen transport, electron …

Prion diseases are invariably fatal neurodegenerative disorders that have gained much
publicity due to their transmissible nature. Sporadic Creutzfeldt-Jakob disease (sCJD) is the …

Recently, we reported β-cleavage of the prion protein (PrP C) in human ocular tissues. Here,
we explored whether this is unique to the human eye, and its functional implications. A …

Prion disorders are a category of neurodegenerative illnesses caused by prions, which are
misfolded proteins. Prions serve as a folding template for proteins during post-translational …