Protective role and functional engineering of neuropeptides in depression and anxiety: an overview

N Okdeh, G Mahfouz, J Harb, JM Sabatier, R Roufayel… - Bioengineering, 2023 - mdpi.com
Behavioral disorders, such as anxiety and depression, are prevalent globally and touch
children and adults on a regular basis. Therefore, it is critical to comprehend how these …

Therapeutic effect of agmatine on neurological disease: focus on ion channels and receptors

S Barua, JY Kim, JY Kim, JH Kim, JE Lee - Neurochemical research, 2019 - Springer
The central nervous system (CNS) is the most injury-prone part of the mammalian body. Any
acute or chronic, central or peripheral neurological disorder is related to abnormal …

Agmatine improves the behavioral and cognitive impairments associated with chronic gestational ethanol exposure in rats

MM Aglawe, MB Kale, SR Rahangdale… - Brain research …, 2021 - Elsevier
Chronic maternal ethanol exposure leads to poor intelligence, impaired cognition and array
of neurological symptoms in offsprings and commonly referred as fetal alcohol spectrum …

Agmatine modulates anxiety and depression-like behaviour in diabetic insulin-resistant rats

M Kale, N Nimje, MM Aglawe, M Umekar, B Taksande… - Brain research, 2020 - Elsevier
Epidemiological studies indicated that mood disorders like depression and anxiety are
highly prevalent in type-II diabetes mellitus (T2DM). However, the neurobiological …

Therapeutic potential of agmatine for CNS disorders

VB Neis, PB Rosa, G Olescowicz… - Neurochemistry …, 2017 - Elsevier
Agmatine is a neuromodulator that regulates multiple neurotransmitters and signaling
pathways. Several studies have focused on elucidating the mechanisms underlying the …

Possible involvement of agmatine in neuropharmacological actions of metformin in diabetic mice

N Kotagale, S Rahangdale, A Borkar, K Singh… - European journal of …, 2021 - Elsevier
The risk of psychiatric and neurological disorders is significantly higher in patients with
diabetes mellitus. Diabetic patients are more susceptible to depression, anxiety and memory …

Agmatine, a potential novel therapeutic strategy for depression

AE Freitas, VB Neis, ALS Rodrigues - European …, 2016 - Elsevier
Major depressive disorder is the most common psychiatric disorder with lifetime prevalence
of up to 20% worldwide. It is responsible for more years lost to disability than any other …

Agmatine prevents the manifestation of impulsive burying and depression-like behaviour in progesterone withdrawn female rats

MD Vinchurney, MD Dhokne, N Kotagale… - Hormones and …, 2023 - Elsevier
Premenstrual dysphoric disorder (PMDD) is characterized by various physical and affective
symptoms, including anxiety, irritability, anhedonia, social withdrawal, and depression. The …

Involvement of hippocampal agmatine in β1-42 amyloid induced memory impairment, neuroinflammation and BDNF signaling disruption in mice

N Kotagale, S Rahmatkar, S Chauragade, M Dixit… - Neurotoxicology, 2020 - Elsevier
Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder
characterized by abnormal accumulation of extracellular β-amyloid (Aβ) plaques and …

[HTML][HTML] Mapping GABAergic projections that mediate feeding

J Wang, M O'Reilly, IA Cooper, F Chehrehasa… - Neuroscience & …, 2024 - Elsevier
Neuroscience offers important insights into the pathogenesis and treatment of obesity by
investigating neural circuits underpinning appetite and feeding. Gamma-aminobutyric acid …