Metal complexes are extensively used for cancer therapy. The multiple variables available
for tuning (metal, ligand, and metal–ligand interaction) offer unique opportunities for drug …

Nanomedicines are extensively employed in cancer therapy. We here propose four strategic
directions to improve nanomedicine translation and exploitation.(1) Patient stratification has …

The tumor accumulation of nanomedicines relies on the enhanced permeability and
retention (EPR) effect. In the last 5–10 years, it has been increasingly recognized that there …

Bioorthogonal chemistry is a powerful tool to site-specifically activate drugs in living systems.
Bioorthogonal reactions between a pair of biologically reactive groups can rapidly and …

Coating the nanoparticle surface with cancer cell recognizing ligands is expected to facilitate
specific delivery of nanoparticles to diseased cells in vivo. While this targeting strategy is …

Metal–organic framework (MOF) materials are gaining significant interest in biomedical
research, owing to their high porosity, crystallinity, and structural and compositional diversity …

Recently, photodynamic therapy (PDT) emerges as a promising way to initiate immune
response and being used in combination with chemotherapy. However, the antitumor effect …

Research activity in medical and cancer nanotechnology has grown dramatically over the
past 15 years. The field has become a cradle of multidisciplinary investigations bringing …

Nanoscale porphyrinic metal–organic frameworks (NMOFs) have emerged as promising
therapeutic platforms for the photodynamic therapy (PDT) of cancer in recent years …

Nanomedicines are extensively explored for cancer therapy. By delivering drug molecules
more efficiently to pathological sites and by attenuating their accumulation in healthy organs …