The multifactorial mechanisms of bacterial infection in decompensated cirrhosis

S Van der Merwe, S Chokshi, C Bernsmeier… - Journal of Hepatology, 2021 - Elsevier
Infections, due to a dysfunctional immune response, pose a great risk to patients with
decompensated cirrhosis and herald the beginning of the terminal phase of this disease …

[HTML][HTML] A double edged sword role of interleukin-22 in wound healing and tissue regeneration

T Arshad, F Mansur, R Palek, S Manzoor… - Frontiers in …, 2020 - frontiersin.org
Wound healing and tissue regeneration is an intricate biological process that involves repair
of cellular damage and maintenance of tissue integrity. Cascades involved in wound healing …

Polystyrene microplastics exacerbate experimental colitis in mice tightly associated with the occurrence of hepatic inflammation

T Luo, D Wang, Y Zhao, X Li, G Yang, Y Jin - Science of The Total …, 2022 - Elsevier
The potential health effects of microplastics (MPs) have become a public concern due to
their ubiquitousness in the environment and life. Numerous studies have demonstrated that …

Extracellular vesicles‐derived miR‐150‐5p secreted by adipose‐derived mesenchymal stem cells inhibits CXCL1 expression to attenuate hepatic fibrosis

Z Du, T Wu, L Liu, B Luo, C Wei - Journal of Cellular and …, 2021 - Wiley Online Library
Hepatic fibrosis (HF) is involved in aggravated wound‐healing response as chronic liver
injury. Extracellular vesicles (EVs) carrying microRNA (miR) have been reported as …

[HTML][HTML] Cellular interplay as a consequence of inflammatory signals leading to liver fibrosis development

SR Ignat, S Dinescu, A Hermenean, M Costache - Cells, 2020 - mdpi.com
Inflammation has been known to be an important driver of fibrogenesis in the liver and onset
of hepatic fibrosis. It starts off as a process meant to protect the liver from further damage, but …

Angelica sinensis polysaccharide attenuates CCl4-induced liver fibrosis via the IL-22/STAT3 pathway

K Wang, J Wang, M Song, H Wang, N Xia… - International Journal of …, 2020 - Elsevier
Angelica sinensis polysaccharide (ASP) has hepatoprotective effects in liver injury models.
However, its role and mechanism in chronic liver fibrosis have not been fully elucidated. In …

Targeted treatment of alcoholic liver disease based on inflammatory signalling pathways

B Wen, C Zhang, J Zhou, Z Zhang, Q Che… - Pharmacology & …, 2021 - Elsevier
Targeted therapy is an emerging treatment strategy for alcoholic liver disease (ALD).
Inflammation plays an important role in the occurrence and development of ALD, and is a …

[HTML][HTML] Therapeutic opportunities of IL-22 in non-alcoholic fatty liver disease: from molecular mechanisms to clinical applications

W Zai, W Chen, H Liu, D Ju - Biomedicines, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) represents one of the most common liver disorders
and can progress into a series of liver diseases, including nonalcoholic steatohepatitis …

Torularhodin Ameliorates Oxidative Activity in Vitro and d-Galactose-Induced Liver Injury via the Nrf2/HO-1 Signaling Pathway in Vivo

C Liu, Y Cui, F Pi, Y Guo, Y Cheng… - Journal of agricultural …, 2019 - ACS Publications
Torularhodin is a natural product extracted from Sporidiobolus pararoseus and has a similar
chemical structure to β-carotene. The antioxidative effects of torularhodin were investigated …

A protective function of IL-22BP in ischemia reperfusion and acetaminophen-induced liver injury

D Kleinschmidt, AD Giannou, HM McGee… - The Journal of …, 2017 - journals.aai.org
Acute liver injury can be secondary to a variety of causes, including infections, intoxication,
and ischemia. All of these insults induce hepatocyte death and subsequent inflammation …