Acute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with
cirrhosis and is characterized by acute decompensation, organ failure (s) and high short …

Liver cirrhosis is an increasing health burden and public health concern. Regardless of
etiology, patients with cirrhosis are at risk of a range of life-threatening complications …

Background: Patients with acutely decompensated cirrhosis (AD) may or may not develop
acute-on-chronic liver failure (ACLF). ACLF is characterized by high-grade systemic …

Background Acute-on-chronic liver failure (ACLF) is a severe complication of cirrhosis and is
defined by organ failure and high rates of short-term mortality. Patients with ACLF are …

Background & Aims Interleukin (IL)-1-type cytokines including IL-1α, IL-1β and interleukin-1
receptor antagonist (IL-1Ra) are among the most potent molecules of the innate immune …

Acute-on-chronic liver failure (ACLF) is a multifaceted condition with poor treatment options
and high short-term mortality. ACLF can develop in patients with or without liver cirrhosis …

Introduction Acute-on-chronic liver failure is a common pattern of end-stage liver disease in
clinical practice and occurs frequently in patients with chronic hepatitis B or HBV-related …

Acute on chronic liver failure (ACLF) is the culmination of chronic liver disease and
extrahepatic organ failures, which is associated with a high short‐term mortality and …

The identification of systemic inflammation (SI) as a central player in the orchestration of
acute‐on‐chronic liver failure (ACLF) has opened new avenues for the understanding of the …

Objective Systemic inflammation predisposes acutely decompensated (AD) cirrhosis to the
development of acute-on-chronic liver failure (ACLF). Supportive treatment can improve AD …