The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

The use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in
the field of transplantation, with excellent short-term outcome. However, the chronic …

Changes in intracellular Ca2+ are central to the function of smooth muscle, which lines the
walls of all hollow organs. These changes take a variety of forms, from sustained, cell-wide …

VSMC s in resistance arteries and arterioles express a diverse array of KV channels with
members of the KV 1, KV 2 and KV 7 families being particularly important. Members of the …

Background: Vasopressin is essential for cardiovascular homeostasis, acting via the kidney
to regulate water resorption, on the vasculature to regulate smooth muscle tone, and as a …

Ca2+ influx through L-type Ca2+ channels (LTCCs) influences numerous physiological
processes ranging from contraction in muscle and memory in neurons to gene expression in …

Hypercontractility of arterial myocytes and enhanced vascular tone during diabetes are, in
part, attributed to the effects of increased glucose (hyperglycemia) on L-type CaV1. 2 …

Potassium channels are tetrameric, membrane-spanning proteins that selectively conduct
K+ at near diffusion-limited rates. Their remarkable ionic selectivity results from a highly …

Voltage‐gated potassium (KV) channels are key regulators of vascular smooth muscle
contractility and vascular tone, and thus have major influence on the microcirculation. KV …