Pharmaceutical cocrystals: along the path to improved medicines

NK Duggirala, ML Perry, Ö Almarsson… - Chemical …, 2016 - pubs.rsc.org
Cocrystals, a long known but understudied class of crystalline solids, have attracted interest
from crystal engineers and pharmaceutical scientists in the past decade and are now an …

A practical guide to the design of molecular crystals

MK Corpinot, DK Bucar - Crystal Growth & Design, 2018 - ACS Publications
This Tutorial Review, aimed at both the novice and the seasoned solid-state chemist,
provides a succinct overview of key findings that have, over the last half century, advanced …

Challenges and opportunities of pharmaceutical cocrystals: a focused review on non-steroidal anti-inflammatory drugs

U Garg, Y Azim - RSC medicinal chemistry, 2021 - pubs.rsc.org
The focus of the review is to discuss the relevant and essential aspects of pharmaceutical
cocrystals in both academia and industry with an emphasis on non-steroidal anti …

ROY reclaims its crown: new ways to increase polymorphic diversity

A Levesque, T Maris, JD Wuest - Journal of the American …, 2020 - ACS Publications
Chemical compounds that exist in multiple crystalline forms are said to exhibit
polymorphism. Polymorphs have the same composition, but their structures and properties …

Co-crystallization and small molecule crystal form diversity: from pharmaceutical to materials applications

S Cherukuvada, R Kaur, TNG Row - CrystEngComm, 2016 - pubs.rsc.org
Co-crystallization is the supramolecular phenomenon of aggregation of two or more different
chemical entities in a crystalline lattice through non-covalent interactions. It encompasses …

[HTML][HTML] Making crystals with a purpose; a journey in crystal engineering at the University of Bologna

D Braga, F Grepioni, L Maini, S d'Agostino - IUCrJ, 2017 - scripts.iucr.org
The conceptual relationship between crystal reactivity, stability and metastability, solubility
and morphology on the one hand and shape, charge distribution, chirality and distribution of …

A rough guide to molecular solid solutions: design, synthesis and characterization of mixed crystals

M Lusi - CrystEngComm, 2018 - pubs.rsc.org
Crystalline solid solutions are long-known solid phases that enable the fine tuning of a
material's structure and properties. Some of them, like metal alloys, have been employed in …

Six-Component Molecular Solids: ABC[D1–(x+y)ExFy]2

M Paul, S Chakraborty, GR Desiraju - Journal of the American …, 2018 - ACS Publications
A strategy has been developed to achieve six-component molecular solids. The first part of
the protocol involves the design and development of a family of stoichiometric quaternary …

Curcumin, a biological wonder molecule: A crystal engineering point of view

P Sanphui, G Bolla - Crystal Growth & Design, 2018 - ACS Publications
Curcumin is a principal active ingredient of turmeric, extracted from the Curcuma longa
plant. The presence of several curcuminoids (eg, curcumin, demethoxycurcumin …

Seeking rules governing mixed molecular crystallization

NM Villeneuve, J Dickman, T Maris, GM Day… - Crystal Growth & …, 2022 - ACS Publications
Mixed crystals result when components of the structure are randomly replaced by analogues
in ratios that can be varied continuously over certain ranges. Mixed crystals are useful …