Amino acids are necessary for all living cells and organisms. Specialized transporters
mediate the transfer of amino acids across plasma membranes. Malfunction of these …

System xc‐is an amino acid antiporter that typically mediates the exchange of extracellular l‐
cystine and intracellular l‐glutamate across the cellular plasma membrane. Studied in a …

Iron dyshomeostasis is implicated in Alzheimer's disease (AD) alongside β-amyloid and tau
pathologies. Despite the recent discovery of ferroptosis, an iron-dependent form cell death …

The transport of amino acids in kidney and intestine is critical for the supply of amino acids to
all tissues and the homeostasis of plasma amino acid levels. This is illustrated by a number …

The SLC7 family is divided into two subgroups, the cationic amino acid transporters (the
CAT family, SLC7A1–4) and the glycoprotein-associated amino acid transporters (the gpaAT …

The small intestine mediates the absorption of amino acids after ingestion of protein and
sustains the supply of amino acids to all tissues. The small intestine is an important …

LAT1 and LAT2 are heterodimeric large amino acid transporters that are expressed in
various tissues, including the intestinal wall, blood–brain barrier, and kidney. These …

The supply of arginine may become rate limiting for enzymatic reactions that use this
semiessential amino acid as a substrate (eg, nitric oxide, agmatine, creatine, and urea …

Cystinuria is a primary inherited aminoaciduria caused by mutations in the genes that
encode the two subunits (neutral and basic amino acid transport protein rBAT and b (0,+) …

Resorption of amino acids in kidney and intestine is mediated by transporters, which prefer
groups of amino acids with similar physico-chemical properties. It is generally assumed that …