In this Timeline, we describe the characteristics of tumour antigens that are recognized by
spontaneous T cell responses in cancer patients and the paths that led to their identification …

Recent developments have set the stage for immunotherapy as a supplement to
conventional cancer treatment. Consequently, a significant effort is required to further …

Repetitive sequences account for more than 50% of the human genome.
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal-dominant disease …

Cancer testis antigens (CTA) are a large family of tumor-associated antigens expressed in
human tumors of different histological origin, but not in normal tissues except for testis and …

Background RNA-Seq has emerged as the standard for measuring gene expression and is
an important technique often used in studies of human disease. Gene expression …

Non-small cell lung cancer (NSCLC) is an aggressive malignancy with increasing worldwide
incidence and is characterized by dismal prognosis due to its early recurrence and …

Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for
which extensive basic knowledge—biochemistry, partners, functions, localizations …

Cancer‑testis antigen (CTA) is a well‑accepted optimal target library for cancer diagnosis
and treatment. Most CTAs are located on the X chromosome and aggregate into large gene …

Background Advanced age is associated with cognitive and physical decline and is a major
risk factor for a multitude of disorders. There is also a gap in life expectancy between males …

Proteins and enzymes in the cell nucleus require physical access to their DNA target sites in
order to perform genomic tasks such as gene activation and transcription. Hence, chromatin …